Table 3.
Effect of once‐daily AZD0530 50mg/kg on human tumor cell xenograft growth in female nude mice.
| Cell line | Origin | Total number of cells inoculated | Average tumor volume before randomization (cm3) | Number of mice randomized to each group (treatment/control) | Duration of dosing (days) | Mean inhibition of tumor volume relative to control (%) |
|---|---|---|---|---|---|---|
| MDA‐MB‐231 | Breast ER− | 5×106 | 0.062 | 9/9 | 27 | 40 |
| AsPc‐1 | Pancreas | 1×107 | 0.3 | 10/10 | 15 | 42 |
| Calu‐6 | Lung | 1×106 | 0.2 | 7/8 | 28 | 40–50a |
| BT474C | Breast ER+ | 1×107 | 0.4 | 12/15 | 21 | 23–34b |
| ZR‐75‐1 | Breast ER+ | 1×107 | 0.5 | 10/10 | 15 | None |
| Colo205 | Colon | 3×106 | 0.3 | 9/9 | 18 | None |
| KB | Oral carcinoma | 5×106 | 0.3 | 8/8 | 10 | None |
| HT29 | Colon | 1×107 | NA | 10/10 | 36–91 | None |
| LoVo | Colon | 1×107 | 0.3 | 7/8 | 14 | None |
| HPAC | Pancreas | 1×107 | 0.3 | 15/15 | 21 | None |
EMEM, Earle's minimal essential medium; NA, not applicable, treatment started on day of inoculation.
a
Range of means observed across eight separate studies.
b
Range of means observed across two separate studies.