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. 2008 Nov 5;3(1):77–83. doi: 10.1016/j.molonc.2008.10.004

Figure 2.

Figure 2

Ebselen decreases invasive potential of glioma cells. (a) Co‐treatment of TNFα treated glioma cells with Ebselen down‐regulates MMP‐9 activity. Gelatin zymography was performed on conditioned medium collected from T98G cells treated with Ebselen in the presence and absence of TNFα. The figure is a representative of two independent experiments with identical results. C, T, E and M denote control, TNFα, Ebselen and marker respectively. (b) Treatment with Ebselen decreases the uPa in TNFα treated glioma cells. uPa activity was performed on conditioned medium obtained from cells treated with TNFα in the presence of Ebselen. Ebselen down‐regulates uPa activity in TNFα treated cells. The graph represents change in uPa activity under different conditions over control which is set to 100%. Values represent the means±SEM from three independent experiments. ** Significant decrease from TNFα treated cells (P<0.05).