Table 2.
Gene sets enriched in the DCIS type I to type II subgroup with FDR q‐value <0.05.
| Enriched in DCIS‐invasive‐like | |||
|---|---|---|---|
| GSEA TermID | Description | No. of genes | FDR q‐val |
| CR_DEATH | Cancer related genes involved in cell death | 69 | 0.020 |
| AMIPATHWAY | Endogenous anti‐thrombosis pathways are overwhelmed in plaque‐narrowed blood vessels, resulting in potentially lethal myocardial infarction. | 21 | 0.029 |
| CSKPATHWAY | Csk inhibits T cell activation by phosphorylating Lck; Csk is regulated by cAMP‐dependent kinases and is opposed by the T cell activator CD45. | 21 | 0.020 |
| CR_IMMUNE_FUNCTION | Cancer related genes involved in immune function | 41 | 0.022 |
| NFKB‐INDUCED | Genes upregulated by NF‐kappa B | 94 | 0.023 |
| EMT_UP | Upregulated during the TGFbeta‐induced epithelial–mesenchymal transition (EMT) of Ras‐transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late‐stage tumour progression and metastasis) | 51 | 0.023 |
| CBF_LEUKEMIA_DOWNING_AML | Genes upregulated in AML samples with the CBF subtype | 64 | 0.020 |
| TCRPATHWAY | T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. | 42 | 0.024 |
| SIG_BCR_SIGNALING_PATHWAY | Members of the B cell antigen receptors (BCR) signaling pathway | 44 | 0.023 |
| CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRANSDUCTION | Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. | 107 | 0.028 |
| NKTPATHWAY | T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. | 20 | 0.029 |
| ST_T_CELL_SIGNAL_TRANSDUCTION | On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. | 40 | 0.039 |
| SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes | 32 | 0.036 |
| BCRPATHWAY | B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. | 34 | 0.033 |
| CCR5PATHWAY | CCR5 is a G‐protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. | 17 | 0.041 |
| ST_TUMOUR_NECROSIS_FACTOR_PATHWAY | Tumour necrosis factor is a pro‐inflammatory cytokine that activates NF‐kB and c‐Jun. | 29 | 0.042 |
| CELL PROLIFERATION | The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population. | 183 | 0.042 |
| ST_B_CELL_ANTIGEN_RECEPTOR | B cell receptors bind antigens and promote B cell activation. | 37 | 0.043 |
| IL12PATHWAY | IL12 and Stat4 Dependent Signaling Pathway in Th1 Development. | 16 | 0.043 |
| RAP_UP | Genes upregulated in response to rapamycin starvation | 149 | 0.043 |