Table 1.
.Hypermethylated and hypomethylated genes in human breast cancer cells.
| Gene | Function | Methylation status |
|---|---|---|
| MGMT | DNA repair | Hyper |
| BRCA1 | Hyper | |
| MLH1 | Hyper | |
| RAD9 | Hyper | |
| LDLRAP1 (ARH1) | Cellular homeostasis | Hyper |
| GPC3 | Hyper | |
| HOXD11 | Hyper | |
| LAMA3 | Hyper | |
| LAMB3 | Hyper | |
| LAMC2 | Hyper | |
| ROBO1 | Hyper | |
| BCSG1 | Cell invasion/metastasis | Hypo |
| CDH1 | Hypo | |
| CDH3 | Hypo | |
| CDH13 | Hyper | |
| CAV1 | Hypo | |
| CST6 | Hyper | |
| NAT1 | Hypo | |
| SYK | Hyper | |
| UPA | Hypo | |
| CCND2 | Cell‐cycle regulation | Hyper |
| 14‐3‐sigma (SFN) | Hyper | |
| AK5 | Hyper | |
| CDKN1C | Hyper | |
| CDKN2A | Hyper | |
| ER | Hyper | |
| FOXA2 | Hyper | |
| PGR | Hyper | |
| RAR‐β | Hyper | |
| RASSF1A | Hyper | |
| RUNX3 | Hyper | |
| SFRP1 | Hyper | |
| WIF1 | Hyper | |
| WRN | Hyper | |
| WT1 | Hyper | |
| APC | Apoptosis | Hyper |
| HIC1 | Hyper | |
| HOXA5 | Hyper | |
| DAPK | Hyper | |
| BCL2 | Hyper | |
| DCC | Hyper | |
| TWIST | Hyper | |
| TMS1 | Hyper |