Tab 3.
IC50 values for the compounds towards individual PI3K isoform.
Class IA PI3K Kinase Assay (IC50 nM)
| PI3K | TGX221 | BL140 | BYL719 | GSK2636771 |
|---|---|---|---|---|
| p110α | 2091 | 878 | 8.619 | 3.54E+06 |
| p110β | 4.813 | 5.744 | 10402 | 20.49 |
| p110δ | 374 | 4247 | 5.92E+06 | 40.53 |
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