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. Author manuscript; available in PMC: 2017 Jul 26.
Published in final edited form as: Neuropsychopharmacology. 2008 Sep 17;34(4):972–986. doi: 10.1038/npp.2008.144

Figure 1.

Figure 1

Membrane potential transition from a hyperpolarized resting potential to a depolarized plateau potential of a medium spiny neuron (MSN) in response to glutamatergic receptor stimulation. (a) Transition in a representative MSN recorded in an acute slice in perforated-patch clamp. Application of 5 μM N-methyl-D-aspartate (NMDA), which mimics cortical synaptic inputs, evoked a reversible membrane potential transition between a hyperpolarized state and a depolarized plateau potential inducing a continuous action potential firing. (b) Periodic spike firing of MSN during the 5 μM NMDA-induced upstate.