Table 4.

Differential Pathway Expression in Normal and Low Responders.

Pathway	p-value
Immune response – IL-17 signaling pathways	0.0005
Immune response – IFNα/β signaling pathway	0.0006
G-protein signaling – Proinsulin C peptide signaling	0.001
Immune response – IL-6 signaling pathway	0.002
Cytokine Production by Th17 cells in CF	0.003
Immune response – CXCR4 signaling via second messenger	0.004
Immune response – Signaling pathway mediated by IL6 and IL-1	0.003
Glycolysis and gluconeogenesis	0.003
Apoptosis and survival – APRIL and BAFF signaling	0.003

MetaCore pathway analysis performed as described in the Methods section.