Table 3.
Hazard ratios (HR) and 95% confidence intervals (CI) for breast cancer incidence in relation to WCRF/AICR adherence score
| Reference |
WCRF/AICR Adherence Scores Unadjusted HR |
WCRF/AICR Adherence Scores Multivariable Adjusted HR |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N Cases/N Total |
Group 1 (0 − 3.5) |
Group 2 (4.0 − 4.5) |
Group 3 (5.0 − 5.5) |
Group 4 (6.0 − 8.0) |
Ptrend1 | Pint | Group 2 (4.0 − 4.5) |
Group 3 (5.0 − 5.5) |
Group 4 (6.0 − 8.0) |
Ptrend1 | Pint | |
|
| ||||||||||||
| Overall2 | 3,189/36,626 | 1.0 (ref) | 1.01 (0.91–1.12) | 1.04 (0.93–1.15) | 0.90 (0.80–1.02) | 0.07 | --- | 0.92 (0.83–1.03) | 0.90 (0.81–1.00) | 0.76 (0.67–0.87) | <0.001 | --- |
|
| ||||||||||||
| Height2,3 | 0.78 | 0.50 | ||||||||||
| ≤160 cm | 742/9,873 | 1.0 (ref) | 1.06 (0.86–1.32) | 1.10 (0.89–1.36) | 0.86 (0.67–1.12) | 0.20 | 0.98 (0.78–1.22) | 0.98 (0.78–1.23) | 0.73 (0.55–0.96) | 0.08 | ||
| >160–<165 cm | 1,400/16,113 | 1.0 (ref) | 0.96 (0.83–1.13) | 0.95 (0.81–1.11) | 0.88 (0.74–1.06) | 0.59 | 0.85 (0.72–1.00) | 0.79 (0.67–0.93) | 0.73 (0.60–0.89) | 0.008 | ||
| ≥ 165 cm | 1,047/10,640 | 1.0 (ref) | 1.02 (0.85–1.23) | 1.10 (0.91–1.32) | 0.92 (0.75–1.14) | 0.31 | 0.99 (0.81–1.20) | 1.02 (0.83–1.24) | 0.84 (0.67–1.05) | 0.24 | ||
|
| ||||||||||||
| Fertility Years3,4,5 | 0.70 | 0.66 | ||||||||||
| ≤ 33 | 978/12,009 | 1.0 (ref) | 1.03 (0.86–1.23) | 1.04 (0.86–1.24) | 0.85 (0.68–1.06) | 0.22 | 0.93 (0.77–1.13) | 0.93 (0.77–1.13) | 0.72 (0.57–0.91) | 0.03 | ||
| 34–38 years | 1,062/12,177 | 1.0 (ref) | 1.02 (0.86–1.22) | 0.96 (0.80–1.15) | 0.95 (0.77–1.17) | 0.82 | 0.90 (0.75–1.08) | 0.78 (0.65–0.95) | 0.74 (0.59–0.92) | 0.02 | ||
| ≥ 39 years | 1,040/10,969 | 1.0 (ref) | 0.94 (0.78–1.13) | 1.04 (0.87–1.25) | 0.88 (0.71–1.09) | 0.28 | 0.92 (0.76–1.12) | 0.98 (0.81–1.19) | 0.81 (0.65–1.01) | 0.18 | ||
|
| ||||||||||||
| Parity6 | 0.12 | 0.09 | ||||||||||
| None | 292/3,272 | 1.0 (ref) | 1.18 (0.84–1.67) | 0.95 (0.67–1.35) | 0.73 (0.48–1.10) | 0.05 | 1.08 (0.75–1.57) | 0.78 (0.53–1.14) | 0.66 (0.42–1.05) | 0.04 | ||
| 1–2 children | 1,074/11,702 | 1.0 (ref) | 0.91 (0.76–1.09) | 1.05 (0.88–1.25) | 0.80 (0.65–0.99) | 0.02 | 0.81 (0.66–0.98) | 0.89 (0.74–1.08) | 0.68 (0.54–0.85) | 0.004 | ||
| 3 or more | 1,277/14,437 | 1.0 (ref) | 1.07 (0.91–1.27) | 1.04 (0.88–1.23) | 0.97 (0.80–1.18) | 0.66 | 1.02 (0.86–1.22) | 0.94 (0.79–1.12) | 0.83 (0.68–1.02) | 0.13 | ||
|
| ||||||||||||
| Family History7,8 | 0.69 | 0.60 | ||||||||||
| None | 2,137/26,766 | 1.0 (ref) | 0.97 (0.85–1.10) | 0.99 (0.88–1.13) | 0.86 (0.75–1.00) | 0.16 | 0.86 (0.76–0.98) | 0.84 (0.74–0.96) | 0.70 (0.60–0.82) | <0.001 | ||
| Second Degree | 392/3,946 | 1.0 (ref) | 1.30 (0.95–1.78) | 1.31 (0.96–1.78) | 1.14 (0.79–1.63) | 0.30 | 1.20 (0.86–1.66) | 1.18 (0.85–1.64) | 1.01 (0.69–1.48) | 0.54 | ||
| First Degree | 523/4,232 | 1.0 (ref) | 1.07 (0.83–1.38) | 1.08 (0.83–1.39) | 0.96 (0.71–1.29) | 0.80 | 0.99 (0.76–1.29) | 0.99 (0.75–1.30) | 0.88 (0.64–1.21) | 0.83 | ||
|
| ||||||||||||
| Combined Factors9 | 0.40 | 0.57 | ||||||||||
| None | 968/11,861 | 1.0 (ref) | 1.02 (0.85–1.23) | 0.96 (0.80–1.16) | 0.94 (0.75–1.17) | 0.41 | 0.92 (0.76–1.11) | 0.81 (0.67–0.99) | 0.74 (0.59–0.93) | 0.001 | ||
| 1 risk factor | 1,241/12,979 | 1.0 (ref) | 0.88 (0.75–1.04) | 1.00 (0.85–1.18) | 0.78 (0.64–0.95) | 0.12 | 0.82 (0.70–0.98) | 0.89 (0.75–1.05) | 0.69 (0.56–0.84) | 0.003 | ||
| 2 risk factors | 627/5,059 | 1.0 (ref) | 1.18 (0.92–1.51) | 1.12 (0.88–1.44) | 1.09 (0.82–1.44) | 0.57 | 1.14 (0.89–1.47) | 1.05 (0.81–1.35) | 0.99 (0.74–1.31) | 0.81 | ||
| 3+ risk factors | 101/651 | 1.0 (ref) | 1.19 (0.63–2.27) | 1.11 (0.59–2.08) | 0.75 (0.35–1.58) | 0.56 | 1.08 (0.57–2.08) | 1.13 (0.60–2.16) | 0.76 (0.36–1.63) | 0.84 | ||
Score evaluated as a continuous variable Cox regression model.
Unadjusted and adjusted for age, smoking, education, hormone replacement therapy, family history of breast cancer, menarche age, menopause age, and parity.
Tertiles.
Age at menopause – age at menarche = years of potential fertility.
Unadjusted and adjusted for age, smoking, education, hormone replacement therapy, family history of breast cancer, and parity.
Unadjusted and adjusted for age, smoking, education, hormone replacement therapy, family history of breast cancer, menopause age, and menarche age.
Unadjusted and adjusted for age, smoking, education, hormone replacement therapy, menopause age, menarche age, and parity.
Breast cancer; second degree = grandmother only, First degree = history in mother/sister.
Unadjusted and adjusted for age, smoking, education and hormone replacement therapy.