Table 1.
Characteristics of patients receiving neoadjuvant therapy for pure squamous cell carcinoma and pure adenocarcinoma of the esophagus
| Squamous Cell Carcinoma (total n = 2,045)
|
Adenocarcinoma (total n = 5,686)
|
|||
|---|---|---|---|---|
| Characteristic | n* | No. (%) or Mean ± SD | n* | No. (%) or Mean ± SD |
| Demographics | ||||
| Age (y) | 2,000 | 61 ± 9.4 | 5,513 | 61 ± 9.8 |
| Female | 2,045 | 678 (33) | 5,686 | 658 (12) |
| Body mass index (mg/kg2) | 1,053 | 23 ± 4.1 | 3,222 | 28 ± 5.2 |
| Weight loss (kg) | 1,067 | 2.6 ± 6.0 | 2,532 | 3.6 ± 7.1 |
| Comorbidities | ||||
| ECOG performance status | 571 | 1,891 | ||
| 0 | 289 (51) | 660 (35) | ||
| 1 | 238 (42) | 1,163 (62) | ||
| 2 | 31 (5.4) | 54 (2.9) | ||
| 3 | 12 (2.1) | 12 (0.63) | ||
| 4 | 1 (0.18) | 2 (0.11) | ||
| Diabetes | 1,798 | 94 (5.2) | 5,091 | 638 (13) |
| IDDM | 1,765 | 16 (0.91) | 4,876 | 67 (1.4) |
| NIDDM | 1,765 | 45 (2.5) | 4,876 | 356 (7.3) |
| Coronary artery disease | 915 | 109 (12) | 3,323 | 486 (15) |
| Arrhythmia | 686 | 23 (3.4) | 1,976 | 43 (2.2) |
| Hypertension | 1,351 | 338 (25) | 3,688 | 1,084 (29) |
| Peripheral arterial disease | 1,102 | 50 (4.5) | 3,363 | 84 (2.5) |
| Smoker | 1,370 | 1038 (76) | 4,324 | 2,902 (67) |
| Past | 1,075 | 444 (41) | 3,527 | 1,552 (44) |
| Current | 1,075 | 299 (28) | 3,527 | 553 (16) |
| FEV1 (% of predicted) | 903 | 90 ± 20 | 2,530 | 95 ± 19 |
| FVC (% of predicted) | 657 | 99 ± 18 | 1,411 | 99 ± 17 |
| Creatinine (μmol/L) | 316 | 73 ± 19 | 667 | 77 ± 20 |
| Bilirubin (μmol/L) | 259 | 12 ± 5.4 | 416 | 9.8 ± 7.5 |
| Decade of treatment | 2,045 | 5,686 | ||
| 1970–1979 | 60 (2.9) | 6 (0.11) | ||
| 1980–1989 | 197 (9.6) | 137 (2.4) | ||
| 1990–1999 | 424 (21) | 826 (15) | ||
| 2000–2009 | 977 (48) | 3,316 (58) | ||
| 2010–2014 | 387 (19) | 1,401 (25) | ||
| Continent | 2,045 | 5,686 | ||
| North America | 973 (48) | 3,880 (68) | ||
| Europe | 568 (28) | 1,367 (24) | ||
| Asia | 408 (20) | 51 (0.9) | ||
| Australia | 94 (4.6) | 379 (6.7) | ||
| South America | 1 (0.049) | 6 (0.11) | ||
| Africa | 1 (0.049) | 3 (0.053) | ||
Patient characteristics of those with adenosquamous and undifferentiated carcinoma are shown in Supporting Information Table S1.
*
Patients with data available.
ECOG, Eastern Cooperative Oncology Group; FEV1 (%), forced expiratory volume in 1 second (percent of predicted); FVC (%), forced vital capacity (percent of predicted); IDDM, insulin-dependent diabetes mellitus; NIDDM, non–insulin-dependent diabetes mellitus; SD, standard deviation.