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. 2011 Jul 7;5(5):454–464. doi: 10.1016/j.molonc.2011.06.005

Figure 2.

Figure 2

(a) Analysis of promoter methylation of candidate genes by MSRA in BC samples. Representative tumor samples (# 3266T, 1099T and 4010T) showing methylated status at different genes, normal breast tissue was unmethylated. M and H: MspI‐ and HpaII digested DNA, respectively. U: undigested DNA. K1 and K2: controls for DNA digestion and integrity, respectively. (b) Frequency of methylation of candidate genes in Early‐onset, Late Onset, ER/PR+ and ER/PR‐ BC. (c) Frequency of overall alterations of candidate genes in Early‐onset, Late Onset, ER/PR+ and ER/PR‐ BC. Significant higher methylation or alteration in ER/PR‐ than ER/PR + BC is shown by asterisk.