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Schematic organisation of classes I, II and IV HDACs showing their domain composition, size, cellular localization, target proteins and the cellular processes which are consequently regulated. The HDAC deacetylase catalytic domains are shown in purple, nuclear localization targeting sequences in yellow, and the ubiquitin‐binding BUZ domain of HDAC6 is in orange. A single substrate example is given alongside each enzyme, as well as the process in which this substrate participates.
