Figure 2.

Influence of HDACs on different cell biological processes and consequences of HDAC inhibition. HDACs are involved in many cellular processes, including progression through the cell cycle, cell differentiation and development, cell migration and motility, angiogenesis and autophagy. These processes could promote tumour cell survival, proliferation and metastasis. HDAC inhibition blocks some of these processes, indicated by red lines, or favours other processes such as apoptosis, here indicated by the green arrow.