Table 6.

Cox proportional regression analyses of factors associated with overall survival and recurrence‐free survival of hepatocellular carcinoma following OLT

Variable	Multivariate analysis
	Overall survival		Recurrence‐free survival
	p‐value	HR (95% CI)	p‐value	HR (95% CI)
Training set (n = 52)
High‐risk miRNA signature	0.007	2.385 (1.296–4.727)	<0.001	4.297 (2.152–9.263)
Tumor grade	0.155	1.687 (0.758–4.140)	0.136	1.856 (0.842–4.179)
Milan criteria (Out/In)	0.013	1.964 (0.642–5.356)	0.016	1.543 (0.379–6.787)
UNOS TNM stage	0.324	1.743 (0.595–4.811)	0.489	1.246 (0.379–3.432)
Tumor size (in cm)	0.098	1.213 (0.978–1.245)	0.056	1.134 (0.967–1.243)
Pre‐OLT serum AFP	0.027	2.192 (1.214–0.003)	0.003	3.157 (1.541–6.253)
Micro‐vascular invasion	0.019	1.836 (0.842–6.708)	0.026	1.870 (0.932–5.965)
Testing set (n = 53)
High‐risk miRNA signature	0.009	2.322 (1.374–4.583)	0.001	3.876 (1.856–8.582)
Tumor grade	0.157	1.813 (0.791–4.220)	0.164	1.753 (0.662–5.963)
Milan criteria (Out/In)	0.030	1.899 (0.770–4.683)	0.021	1.823 (0.796–5.734)
UNOS TNM stage	0.505	1.697 (0.359–8.033)	0.475	1.461 (0.419–6.491)
Tumor size (in cm)	0.081	1.142 (0.900–1.296)	0.077	1.232 (0.957–1.552)
Pre‐OLT serum AFP	0.027	2.156 (1.276–4.163)	0.015	4.095 (1.313–9.772)
Micro‐vascular invasion	0.015	1.968 (0.972–7.899)	0.021	2.109 (0.987–8.602)
Validation set (n = 50)
High‐risk miRNA signature	0.004	2.241 (1.238–4.356)	0.001	3.590 (1.541–8.384)
Tumor grade	0.179	1.747 (0.895–4.131)	0.155	1.789 (0.962–5.357)
Milan criteria (Out/In)	0.021	1.783 (0.894–4.748)	0.024	1.874 (0.802–5.695)
UNOS TNM stage	0.533	1.769 (0.593–8.217)	0.576	1.468 (0.456–6.179)
Tumor size (in cm)	0.063	1.131 (0.994–1.378)	0.079	1.344 (0.987–1.427)
Pre‐OLT serum AFP	0.019	2.231 (1.367–4.293)	0.024	3.795 (1.464–7.792)
Micro‐vascular invasion	0.014	2.329 (0.902–7.573)	0.011	2.579 (0.974–6.854)