Table 7.
Cox proportional regression analysis according to Milan criteria stratification for hepatocellular carcinoma
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OS | RFS | OS | RFS | |
| p‐value | p‐value | p‐value | p‐value | |
| Patients within Milan criteria (n = 56) | ||||
| Six miRNA signature | 0.022 | 0.017 | 0.029 | 0.015 |
| Tumor size (in cm) | 0.073 | 0.087 | – | – |
| Pre‐OLT serum AFP | 0.018 | 0.024 | 0.091 | 0.015 |
| Tumor grade | 0.337 | 0.455 | – | – |
| Micro‐vascular invasion | 0.019 | 0.025 | 0.032 | 0.027 |
| Patients outside Milan criteria (n = 47) | ||||
| Six miRNA signature | 0.026 | 0.003 | 0.035 | 0.018 |
| Tumor size (in cm) | 0.178 | 0.092 | – | – |
| Pre‐OLT serum AFP | 0.392 | 0.256 | – | – |
| Tumor grade | 0.013 | 0.008 | 0.179 | 0.092 |
| Micro‐vascular invasion | 0.016 | 0.011 | 0.025 | 0.033 |