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. 2012 Oct 23;7(1):121–129. doi: 10.1016/j.molonc.2012.10.001

Figure 1.

Figure 1

EGFR is important for proteolytic enzyme expression and ovarian cancer invasion. The serum‐starved PA‐1 (A) and SKOV‐3 (B) cells were pretreated with gefitinib for 1 h and then stimulated with LPA for 24 h. mRNA expression of MMP‐9 and uPA by quantitative RT‐PCR (Error bars, ± s.d. ∗p < 0.01 and ∗∗p < 0.001 vs control, #p < 0.05 vs EGF treatment only, $p < 0.05 vs LPA treatment only). The serum‐starved PA‐1 (C) and SKOV‐3 (D) cells were pretreated with gefitinib for 1 h and in vitro invasion was analyzed against LPA (Error bars, ± s.d. ∗p < 0.01). All experiments were repeated three times.