Table 2.
List of current GEM models of PDAC.
| GEM model | Lesions | Metastasis | Survival | References |
|---|---|---|---|---|
| Pdx1‐Cre; K‐Ras+/LSLG12D; Ink4a/Arflox/lox | PanIN and PDAC | Yes | 2 m | Aguirre et al., 2003 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; p53R172H/+(KPC) | PanIN and PDAC | Yes | 5 m | Hingorani et al., 2005 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; Ink4a/Arf−/− | PanIN and PDAC | Yes | 5 m | Bardeesy et al., 2006 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; p53lox/lox | PanIN and PDAC | No | 3 m | Bardeesy et al., 2006 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; p53lox/lox; Ink4a/Arf−/− | PanIN and PDAC | Yes | 2 m | Bardeesy et al., 2006 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; Smad4lox/lox | IPMN and PDAC | Yes | 9 m | Bardeesy et al., 2006 |
| Ptf1a‐Cre; K‐Ras+/LSLG12D; TGFβIIRlox/lox | PanIN and PDAC | Yes | 2 m | Ijichi et al., 2006 |
| Elastase‐tTA; Tet‐O‐Cre; K‐Ras+/LSLG12Vgeo; p53−/− | PanIN and PDAC | Yes | 3–4 m | Guerra et al., 2007 |
| Ptf1a‐Cre; K‐Ras+/LSLG12D; Elastase‐TGF‐α | PanIN, IPMN, PDAC | Yes | 7 m | Siveke et al., 2007 |
| Ptf1a‐Cre; K‐Ras+/LSLG12D; Smad4lox/lox | MCN and PDAC | Yes | 8 m | Izeradjene et al., 2007 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; Brca2Tr/Δ11 | PanIN and PDAC | NA | NA | Skoulidis et al., 2010 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; p53R270H/+; Brca2Tr/+ | PanIN and PDAC | NA | <5 m | Skoulidis et al., 2010 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; p53R270H/+; Brca2Tr/Δ11 | PanIN and PDAC | Yes | 2.5 m | Skoulidis et al., 2010 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; Lkb1lox/lox | PanIN and PDAC | NA | 4.5 m | Morton et al., 2010 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; Notch1lox/lox | PanIN (high grade) | No | 3 m | Hanlon et al., 2010 |
| Ptf1a‐Cre; K‐Ras+/LSLG12D; Notch2lox/lox | MCN, anaplastic, PDAC | No | >12 m | Mazur et al., 2010 |
| Elastase‐tTA; Tet‐O‐Cre; K‐Ras+/LSLG12Vgeo; p53lox/lox | PanIN and PDAC | Yes | 3–4 m | Guerra et al., 2011 |
| Elastase‐tTA; Tet‐O‐Cre; K‐Ras+/LSLG12Vgeo; Ink4a/Arflox/lox | PanIN and PDAC | Yes | 3–4 m | Guerra et al., 2011 |
| Pdx1‐Cre; K‐Ras+/LSLG12D; Usp9x+/lox | PanIN and PDAC | NA | NA | Perez‐Mancera et al., 2012 |
m: Months; NA: Not analyzed.