Table 1.

Comparison of the respective features of different technologies used to obtain mouse models of leukaemia.

	Advantages	Drawbacks
Xenografts	• Human diseases • Ready to use	• Engraftment difficulties • Experimental reproducibility • Transplantability? • Cohorts size and homogeneity
Viral transformation‐derived models	• Fast • Allow large‐scale experiments	• Choice of oncogene(s) • Insertion site issues
Transgenics‐derived models	• Reproducible • Allow large‐scale experiments	• Choice of transgene(s) • Choice of promoter/cell type specificity issue • Time‐consuming