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. 2013 Jul 20;7(6):1012–1018. doi: 10.1016/j.molonc.2013.07.010

Figure 1.

Figure 1

Upregulation of SESN2 by the endoplasmic reticulum stress reaction. A) MDA‐MB‐453 breast cancer cells were treated with 15 μg/mL nelfinavir (NFV) for the indicated time periods, and cell extracts were subjected to Western blot analysis. B) MDA‐MB‐453 cells were treated with 100 nM thapsigargin (THA), 1 μg/mL tunicamycin (TUN), 15 μg/mL nelfinavir (NFV), 15 ng/mL bortezomib (BTZ), 25 μg/mL etoposide (ETO), 50 ng/mL taxol (TAX), and 1.5 μg/mL cisplatin (CIS) for 16 h and investigated by Western blot analysis. C) OVCAR3 cells were treated with 50 nM thapsigargin (THA), 1 μg/mL tunicamycin (TUN), 15 μg/mL nelfinavir (NFV), 60 ng/mL doxorubicin (DOX), 100 ng/mL taxol (TAX), and 100 μg/mL carboplatin (CP) for 16 h and analyzed as above. D) HeLa cells were treated and analyzed as in (b).