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. 2013 Jul 20;7(6):1012–1018. doi: 10.1016/j.molonc.2013.07.010

Figure 6.

Figure 6

Interaction of ER stress, proteasome inhibition, ATF4 expression, SESN2 expression, and mTOR activity. This schematic represents an integrated view of ATF4‐regulated SESN2 expression in the context of current knowledge about the relations between ER stress, proteasome inhibition, mTOR activity, and autophagy. Both nelfinavir and bortezomib lead to mTOR inhibition through elevating ATF4 and SESN2 expression. mTOR itself is a positive regulator of protein biosynthesis and a negative regulator of autophagy.