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Suppression of vimentin enhanced sensitivity to ALK inhibitors in H2228/CR cells. (A) Control, E‐cadherin, and vimentin siRNA (100 nM) were introduced to the parental or resistant cells, and the suppression of each protein was confirmed by Western blot analysis. (B) After the transfection of each siRNA, cells were treated with the indicated doses of crizotinib or TAE‐684, and cell viability was measured 72 h later using the MTT assay. Bars represent the standard deviations.
