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. 2013 Aug 16;7(6):1043–1055. doi: 10.1016/j.molonc.2013.08.003

Figure 6.

Figure 6

Ad‐TRAIL‐3MREs prevented liver tissue from cytotoxicity in mice. (A) TRAIL expression was investigated in liver tissues of the mice treated with indicated adenoviruses or PBS by immunohistological staining. The representative images were shown (×200). (B) Immunoblotting assay showed the expression of TRAIL and apoptotic pathway‐related proteins, including cleaved caspase 3 and PARP, in liver tissues of tumor‐bearing mice treated by adenoviruses. GAPDH was used as loading control. (C) 3 × 109 pfu of indicated adenoviruses or PBS was intravenously injected into 20 tumor‐free mice (4 group; n = 5). Subsequently, their blood was harvested to evaluate ALT levels. Means ± SD were shown.