Table 2.

Univariate (A) and multivariate (B) analysis of different clinico‐pathological and genomic variables in relation to the M5‐15 class in the ER+ HER2− untreated group (N = 140).

Class DMa	Variable	P value	OR	95% CI
A. Univariate analysis of clinical pathological markers and MammaPrint in relation to Late Distant Metastasis (DM) class
M5‐15	Age (<55 yr vs ≥ 55 yr)	0.16	0.56	0.24–1.27
	Histology (IDC vs others)	0.50	0.68	0.22–2.11
	Diameter (≤2 cm vs > 2 cm)	0.08	0. 46	0.19–1.09
	Lymph node status (0 vs 1+)	0.01	0.15	0.04–0.59
	Grade (1,2 vs 3)	0.85	0.91	0.33–2.47
	Grade (1 vs 2, 3)	0.12	0.52	0.23–1.18
B. Multivariate analysis of clinical pathological markers and MammaPrint in relation to Late Distant Metastasis (DM) class
M5‐15	Age (<55 yr vs ≥ 55 yr)	0.12	0.50	0.21–1.20
	Diameter (≤2 cm vs > 2 cm)	0.24	0.57	0.23–1.45
	Lymph node status (0 vs 1+)	0.005	0.14	0.03–0.56
	Grade (1 vs 2, 3)	0.16	0.52	0.21–1.28

Abbreviations: yr = years; OR = Odds Ratio; CI = Confidence Interval.

^aThe reference class is M0.