Figure 5.

Evaluation of vvDD activity in the metastatic sarcoma experimental model. 143B cells labeled with mCherryFluc were injected intravenously through the tail vein of CB17 SCID mice to generate a commonly used model of lung metastatic lesions. Imaging analysis showed progressively increasing lung lesions in these animals. After allowing 14 days for the lesions to establish, the animals received a single dose of vvDD or killed virus (5 animals per group). Bioluminescent imaging was carried out at weekly intervals for up to 3 weeks (A) and corresponding tumor size measurements were made from the images (B) (N.S.: not statistically significant).