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Frequency of exon 9 and exon 20 hot spot mutations among PIK3CA mutant breast cancer (modified after www.mycancergenome.com).
| Gene | Exon | Location | Amino Acid position | Amino Acid change | Nucleotide change | Mutation frequency |
|---|---|---|---|---|---|---|
| PIK3CA | 9 | Helical domain | E542 | p.E542K | c.1624G > A | 11% |
| E545 | p.E545K | c.1633G > A | 20% | |||
| p.E545G | c.1634A > G | <1% | ||||
| 20 | Kinase domain | H1047 | p.H1047R | c.3140A > G | 55% |
