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. 2012 Oct 29;7(3):308–322. doi: 10.1016/j.molonc.2012.10.002

Figure 7.

Figure 7

Effect of Rucaparib in combination with radiotherapy on apoptosis and autophagy. Cells were incubated with 1 μM Rucaparib for 72 h and after the first 24 h were exposed to a radiation dose of 4–10 Gy. (A) Apoptosis was measured as described in the Material and methods section and results of three independent experiments are reported as histograms. (B) ICC confirmation of autophagy induction in treated MiaPaCa‐2 cells through the determination of LC3‐stained autophagic compartments is reported as punctate dots (blue: DAPI; green LC3).