Table 6.

PANTHER over‐representation analysis of target genes list.

PANTHER classification category	Number of genes			Over‐/under‐represented (+/−)	p‐value	% of target listd
	Reference lista	Target listb	Expectedc
Pathways
Insulin/IGF pathway‐MAPKK/MAP kinase cascade	38	4	0.09	+	3.23E‐04	8.89
Angiogenesis	185	6	0.42	+	6.63E‐04	13.33
Interleukin signaling pathway	112	5	0.25	+	9.88E‐04	11.11
Gonadotropin‐releasing hormone receptor pathway	282	6	0.63	+	7.07E‐03	13.33
Insulin/IGF pathway‐PKB signaling cascade	38	3	0.09	+	1.62E‐02	6.67
Molecular functions
Transmembrane receptor protein kinase activity	120	5	0.27	+	1.16E‐03	11.11
Protein kinase activity	500	8	1.12	+	2.14E‐03	17.78
Kinase activity	664	8	1.49	+	1.58E‐02	17.78
Transmembrane receptor protein serine/threonine kinase activity	52	3	0.12	+	3.42E‐02	6.67
Biological Processes
Protein amino acid phosphorylation	654	10	1.47	+	2.66E‐04	22.22
Cellular process	6072	29	13.66	+	4.24E‐04	64.44
Signal transduction	4019	22	9.04	+	2.49E‐03	48.89
Cell communication	4224	22	9.50	+	5.65E‐03	48.89
Transmembrane receptor protein tyrosine kinase signaling pathway	295	6	0.66	+	8.76E‐03	13.33
MAPKKK cascade	454	7	1.02	+	1.13E‐02	15.56
Protein modification process	1330	11	2.99	+	2.34E‐02	24.44
Cell cycle	1602	12	3.60	+	2.78E‐02	26.67

Pathways, molecular function classes and biological processes resulted significantly over or under represented by 46 gene targets.

^aNumber of genes in the reference list that map to this PANTHER classification category.

^bNumber of genes in the target genes list that map to this PANTHER classification category.

^cExpected value is the number of genes that could be expected in target genes list for this PANTHER category based on the reference list.

^dPercentage of genes in the target list out of the total considered genes in PANTHER (n=45). P‐values are determined by binomial statistics with Bonferroni correction: a p‐value cut‐off of 0.05 was considered.