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. 2013 Dec 18;8(2):378–388. doi: 10.1016/j.molonc.2013.12.006

Figure 2.

Figure 2

Effect of CDDP and 5FU treatment on growth of a panel of human cancer‐derived cell lines. Waterfall plots showing the effect of CDDP (A) and 5FU (B) on cancer cell growth. 28 human cancer‐derived cell lines were grown in the presence of increasing concentrations (0.1–1.0–10 μM) of either CDDP or 5FU as adherent cells. Cell growth was assessed 48 h after treatment start and measured by ATP cellular content. Growth rates are expressed as percentage over placebo‐treated cells. (C) Waterfall plot showing the effect of CDDP in combination with anti MET antibody on growth of not MET addicted cancer cells. Cells were incubated with: placebo; CDDP (10 μM) or MV‐DN30 plus CDDP (125 nM and 10 μM respectively). Growth rates are expressed as percentage over placebo‐treated cells. (D) Waterfall plot showing the effect of 5FU in combination with MV‐DN30 on growth of not addicted cancer cells. Cells were incubated with: placebo; 5FU (10 μM) or MV‐DN30 plus 5FU (125 nM and 10 μM respectively). Growth rates are expressed as percentage over placebo‐treated cells. Data are means ± SD of three independent experiments performed in triplicates.