Figure 2.

The modular hub genes are differentially expressed in gastric cancer subtypes. (A) Two way hierarchical clustering of the expression of top 25 hub genes of all modules in the gastric tumor mRNA profile, GSE15459 shows the elevated expression of G1, G2, G3, and G5 modules in poorly differentiated tumors. G13 module is expressed in moderately differentiated gastric tumors. In all the heat maps highest to lowest expression is represented by red to green. (B) Expression and clustering pattern of modular genes in an independent cohort of gastric tumors (GSE22377) indicate the expression of G1, G2, G3, and G5 modules in diffuse type gastric tumors and G13 in intestinal type.