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. 2014 Jun 13;8(8):1508–1520. doi: 10.1016/j.molonc.2014.06.004

Figure 5.

Figure 5

Effects of mTOR inhibitor Everolimus in the growth of four UM PDXs in vivo. Growth curves of four human uveal melanoma xenografts: MP46 (A), MP55 (B), MP34(C), and MP41(D), treated with Everolimus (Δ) per os at 2 mg/kg 3 times a week, or receiving vehicle (■) with the same schedule as the treated animals for 4 (MP46, MP55, MP34) to 6 (MP41) weeks. Tumor volume and RTV were calculated as described in Materials and Methods. Growth curves were obtained by plotting mean RTV against time. Bars, SD. For the treated groups n = 6–8 mice; for the control groups n = 8–10 mice. P values calculated at the end of the treatment were <0.05 for the four models.