Skip to main content
. 2014 Jan 18;8(3):609–619. doi: 10.1016/j.molonc.2013.12.019

Figure 5.

Figure 5

In vivo efficiency in a patient‐derived (PDX) melanoma xenograft model. (A) The application of the small‐size MIDGE‐hTNFα vector in PDX melanoma shows significantly reduced tumor growth in vivo. (B) Immunohistochemistry staining for hTNFα detection in the treated and non‐treated melanoma PDX. (C) Intratumoral detection of apoptosis in the treated and non‐treated melanoma PDX using TUNEL‐assay. The relative tumor volumes are in mean ± SEM. One way ANOVA followed by Dunnett's Multiple Comparison Test vs. untreated group was used for statistical analysis. Scale bar represents 100 μm and 50 μm (inset).