Table 1.

Predictive analysis of interaction between TP53 and treatment on Overall Survival (A: OS) and Disease‐Free Interval (B: DFS).

A		Treatment arm		Observation arm		HR, treatment vs observation	[95% CI]	p‐value
OS		Deaths	Patients	Deaths	Patients
	Wild Type (WT)	89	144	88	159	0.99	0.73–1.34	0.93
	Mutant (MT)	87	120	60	101	1.36	0.97–1.91	0.08
	HR, MT vs WT	1.27		0.92		Test for interaction TP53*Treatment		0.17
	[95% CI]	(0.93–1.73)		(0.65–1.29)
	p‐value	0.14		0.63
B		Treatment arm		Observation arm		HR, Treatment vs Observation	[95% CI]	p‐value
DFS		Events	Patients	Events	Patients
	Wild Type (WT)	92	144	98	159	0.93	(0.69–1.24)	0.60
	Mutant (MT)	89	120	63	101	1.40	(1.01–1.95)	0.04
	HR, MT vs WT	1.29		0.85		Test for interaction TP53*Treatment		0.06
	[95% CI]	(0.95–1.75)		(0.61–1.18)
	p‐value	0.11		0.33