Table 5.
p53‐negative | p53‐positive | Treatment effect by mutation status | ||||
---|---|---|---|---|---|---|
Treatment am | Observation arm | Treatment arm | Observation arm | HR, [95% CI] (a) | p‐value | |
Wild‐Type TP53 | ||||||
nb deaths/total | 57/91 | 61/101 | 31/52 | 28/57 | 1.00, [0.74–1.35] | p = 0.97 |
HR, [95% CI] (a) | 0.85, [0.58–1.23] (b) | 1.28, [0.75–2.18] (b) | ||||
p‐value | p = 0.38 | p = 0.37 | ||||
Mutant TP53 | ||||||
nb deaths/total | 34/46 | 28/42 | 53/74 | 32/59 | 1.37, [0.97–1.91] | p = 0.07 |
HR, [95% CI] (a) | 1.35, [0.80–2.26] (b) | 1.40, [0.89–2.19] (b) | ||||
p‐value | p = 0.26 | p = 0.14 | ||||
Treatment effect by p53 expression status | ||||||
HR, [95% CI] (a) | 0.99 [0.74–1.34] | 1.38 [0.98–1.94] | ||||
p‐value | p = 0.95 | p = 0.07 |
(a): HR for death, treatment vs Observation, [95% CI].
(b): Test of the equality of the four HR: p = 0.28.