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. 2014 Jan 15;8(3):555–564. doi: 10.1016/j.molonc.2013.12.015

Table 5.

Predictive effect of TP53 mutation status on overall survival (OS) according to p53 protein expression level.

p53‐negative p53‐positive Treatment effect by mutation status
Treatment am Observation arm Treatment arm Observation arm HR, [95% CI] (a) p‐value
Wild‐Type TP53
nb deaths/total 57/91 61/101 31/52 28/57 1.00, [0.74–1.35] p = 0.97
HR, [95% CI] (a) 0.85, [0.58–1.23] (b) 1.28, [0.75–2.18] (b)
p‐value p = 0.38 p = 0.37
Mutant TP53
nb deaths/total 34/46 28/42 53/74 32/59 1.37, [0.97–1.91] p = 0.07
HR, [95% CI] (a) 1.35, [0.80–2.26] (b) 1.40, [0.89–2.19] (b)
p‐value p = 0.26 p = 0.14
Treatment effect by p53 expression status
HR, [95% CI] (a) 0.99 [0.74–1.34] 1.38 [0.98–1.94]
p‐value p = 0.95 p = 0.07

(a): HR for death, treatment vs Observation, [95% CI].

(b): Test of the equality of the four HR: p = 0.28.