Table 3.
List of regions differentiating the clusters defined in HGSOCs.
| Cytoband | Start [bp] | End [bp] | Size [bp] | Nr of genes | Frequency in cluster A [%] | Frequency in cluster B [%] | Difference | Cancer gene census | P | HR | 95% CI | P adj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6q24.2 – q26 | 145,593,087 | 162,867,181 | 17,274,094 | 169 | 14.29 | 75.55 | 61.26 | 0.001 | 0.06 | 0.01 | 0.43 | 0.005 | |
| 11p15.5–15.3 | 0 | 12,467,187 | 12,467,187 | 393 | 9.56 | 67.65 | 58.09 | HRAS CARS NUP98 LMO1 | 0.07 | 0.30 | 0.06 | 1.41 | 0.13 |
| 16q21 | 62,541,693 | 64,974,691 | 2,432,998 | 4 | 25.00 | 76.92 | 51.92 | CDH11 | 0.71 | 0.62 | 0.15 | 2.60 | 0.51 |
| 19q13.31 – q13.32 | 48,908,403 | 51,085,851 | 2,177,448 | 73 | 1.56 | 51.92 | 50.36 | BCL3 CBLC ERCC2 | 0.17 | 0.31 | 0.04 | 2.34 | 0.26 |
| 22q12.3 – q13.1 | 35,051,869 | 37,251,402 | 2,199,533 | 110 | 25.00 | 78.85 | 53.85 | MYH9 | 0.56 | 0.25 | 0.04 | 1.56 | 0.14 |
| 22q13.2 – q13.31 | 39,940,439 | 46,673,931 | 6,733,492 | 105 | 26.25 | 80.77 | 54.52 | 0.72 | 0.53 | 0.08 | 3.30 | 0.49 | |
Regions differentiating clusters (Clusters A and B) in the high‐grade serous ovarian carcinomas (HGSOCs) defined to be at least 35% more frequent in one of the clusters and significant after correction for multiple testing (FDR <0.05); all the regions were tested for the association with overall survival (OS), highlighted regions were significantly associated with better prognosis (P < 0.05), P‐values‐calculated in the univariate analysis with the log‐rank test; Padj as calculated in multivariate Cox regression model in which significant covariates were included; HR, Hazard Ratio; CI, Confidence Intervals.