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. 2014 Aug 27;9(1):249–259. doi: 10.1016/j.molonc.2014.08.002

Figure 1.

Figure 1

Overexpression of Aurora‐A promotes ESCC tumor invasion and metastasis. A) The effect of Aurora‐A overexpression on cell migration and invasion ability in vitro. The results were from three separate experiments; bars, SD.*, P < 0.01. B) Aurora‐A overexpression promoted tumor growth in vivo. The xenograft tumor volume was measured at the indicated time points during the period of 12 weeks. C–F) Aurora‐A overexpression promoted tumor cell invasion and metastasis in vivo. Representative images were shown. The mice baring tumor xenografts derived from KYSE150 cells overexpressing Aurora‐A exhibited tumor invasion to the adjacent muscle tissues (C), small tumor masses in blood vessels (D), lymph node metastasis (E), and lung metastasis (F). Arrows indicate the presence of tumor invasion to the adjacent muscle tissues or metastatic tumor in tumor or lung slice.