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. 2015 Feb 18;9(6):1129–1139. doi: 10.1016/j.molonc.2015.02.005

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© 2015 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Three‐dimensional principal components plot based expression of the 1000 gene probes with highest variance across eight neurofibromas (blue spheres) and 30 MPNST samples (red) (A). *Samples with RIN values between 3 and 5. Percentagewise distribution over 43 chromosome arms of Entrez annotated gene probes on the AB1700 microarray (N = 11,596 genes) (expected distribution; red bars) compared to the distribution of the significantly upregulated genes (N = 337) in MPNST vs neurofibroma (observed distribution; blue bars) (B). Statistical significance of the deviation between observed and expected distribution of the N = 337 upregulated genes in MPNST vs neurofibroma as sorted by the P‐value from a binomial distribution test, cumulative probability, P (X ≥ x) (C).