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In vitro binding of OPB‐31221 to the STAT3 SH2 domain. (A) Isothermal titration calorimetry (ITC) data for the STAT3 SH2 domain/OPB‐31121 system. (B) ITC data for the STAT3 SH2 domain/S3I.201 system. (C) ITC analysis of OPB‐31121 interaction with the STAT3 SH2 domain after pre‐incubation with S3I.201.
