Table 1.
Pathological characteristics of tumors with reference to site of origin and histopathology. Number of mRNA and miRNA samples from PDAC (P) (n = 49, n = 52), bile duct (P) (n = 8, n = 8), ampulla (P) (n = 8, n = 8), ampulla (I) (n = 7, n = 7), Duodenum (I) (n = 9, n = 9), normal (n = 12, n = 6).
| Periampullary adenocarcinomas total number = 85 | PDAC (P) | Bile duct (P) | Ampulla (P) | Ampulla (I) | Duodenum (I) | |
|---|---|---|---|---|---|---|
| Total (P) number, n = 68 | Total (I) number, n = 17 | |||||
| Number (%) | Number (%) | Number (%) | Number (%) | Number (%) | ||
| Histopathology of PAs | Pancreato‐biliary | 52 (76.5) | 8 (11.8) | 8 (11.8) | 0 | 0 |
| Intestinal | 0 | 0 | 0 | 7 (41.2) | 10 (58.8) | |
| Differentiation grade of tumors | Poor | 20 (38.4) | 4 (50) | 4 (50) | 0 | 2 (20) |
| Moderate | 31 (59.6) | 4 (50) | 4 (50) | 7 (100) | 8 (80) | |
| Well | 1 (1.9) | 0 | 0 | 0 | 0 | |
| pT | T1 | 4 (7.7) | 0 | 0 | 0 | 1 (10) |
| T2 | 5 (9.6) | 0 | 0 | 6 (85.7) | 2 (20) | |
| T3 | 43 (82.7) | 8 (100) | 5 (62.5) | 1 (14.3) | 3 (30) | |
| T4 | 0 | 0 | 3 (37.5) | 0 | 4 (40) | |
| N | N0 | 12 (23) | 4 (50) | 5 (62.5) | 4 (57.1) | 4 (40) |
| N1 | 40 (76.9) | 4 (50) | 3 (37.5) | 3 (42.8) | 5 (50) | |
| N2 | – | – | – | – | 1 (10) | |
| M | M0 | 50 (96.1) | 8 (100) | 8 (100) | 7 (100) | 8 (80) |
| M1 | 2 (3.8) | 0 | 0 | 0 | 2 (20) | |
| R | R0 | 22 (42.3) | 6 (80) | 7 (90) | 7 (100) | 9 (90) |
| R1 | 30 (57.6) | 2 (20) | 1 (10) | 0 | 1 (10) | |
| Vessel infiltration | Yes | 26 (50) | 4 (50) | 5 (62.5) | 2 (28.5) | 7 (70) |
| No | 26 (50) | 4 (50) | 3 (37.5) | 5 (71.4) | 3 (30) | |
| Perineural infiltration | Yes | 51 (98) | 7 (87.5) | 7 (87.5) | 1 (14.28) | 3 (30) |
| No | 1 (2) | 1 (12.5) | 1 (12.5) | 6 (85.7) | 7 (70) | |
| KRAS mutations in codons 12 and 13 | Mutated | 45/52 (87) | 6/8 (75) | 6/8 (75) | 2/7 (29) | 6/10 (60) |
| Wild type | 7/52 (13) | 2/8 (25) | 2/8 (25) | 5/7 (71) | 4/10 (40) | |