Table 2.
The number of interactions between miRNAs and mRNAs, miRNA families and the miRNAs and mRNAs (i.e., genes) linked to better RFS and OS with reference to enriched pathways.
| Pathways | Interactions (miRNA‐mRNA) | Pancreatobiliary prognostic markers (miRNA and mRNA) | Intestinal prognostic markers (miRNA and mRNA) | miRNA family |
|---|---|---|---|---|
| Insulin regulation and recycling | 175 (40–45) | CALM1, PCK2, SLC2A4, PDPK1, PPARGC1A, PIK3R1, PHKB, hsa‐miR‐196b, hsa‐miR‐497 | FBP1, G6PC, PCK2, PIK3R2, PDPK1, hsa‐miR‐424, hsa‐miR‐382, hsa‐miR‐127‐3p, hsa‐miR‐193b*, hsa‐miR‐365, hsa‐miR‐455‐3p, hsa‐miR‐335 | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐329 |
| Wnt signaling | 163 (40–38) | LRP6, CXXC4, PPARD, CCND2, hsa‐miR‐196b, hsa‐miR‐497, has‐miR‐592 | WNT5A, CAMK2G, VANGL1, NFATC4, hsa‐miR‐455‐3p, hsa‐miR‐335, hsa‐miR‐193b*, hsa‐miR‐365, hsa‐miR‐424, hsa‐miR‐127‐3p | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐154 |
| E2F | 162 (43–27) | RB1, ATM,E2F7 | E2B2, CEBPA, hsa‐miR‐193b*, hsa‐miR‐365, hsa‐miR‐654‐3p, hsa‐miR‐424, hsa‐miR‐127‐3p, hsa‐miR‐377*, hsa‐miR‐455‐3p, hsa‐miR‐335 | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐154 |
| PPAR | 150 (44–38) | PIK3R1, RB1, RXRA, PCK2, PDPK1, PPARD, PTGS2 | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐154, miR‐329 | |
| p73 | 117 (43–23) | BBC3, WT1, GATA1, RB1, ITCH | hsa‐miR‐193b*, hsa‐miR‐654‐3p, hsa‐miR‐424, hsa‐miR‐127‐3p, hsa‐miR‐335 | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐154, miR‐329 |
| ATM | 107 (43–12) | ATM, hsa‐miR‐196b, hsa‐miR‐497 | hsa‐miR‐365, hsa‐miR‐654‐3p, hsa‐miR‐424, hsa‐miR‐127‐3p, hsa‐miR‐377*, hsa‐miR‐455‐3p, hsa‐miR‐335 | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐154 |
| p53 | 76 (46–17) | RB1, PTEN, BBC3, hsa‐miR‐196b, hsa‐miR‐497, has‐miR‐592 | GADD45B, hsa‐miR‐485‐3p, hsa‐miR‐193b*, hsa‐miR‐365, hsa‐miR‐654‐3p, hsa‐miR‐424, hsa‐miR‐127‐3p, hsa‐miR‐377*, hsa‐miR‐455‐3p, hsa‐miR‐335 | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐154, miR‐329 |
| Interferon/cytokine | 66 (29–14) | hsa‐miR‐196b, hsa‐miR‐497 | hsa‐miR‐377*, hsa‐miR‐455‐3p, hsa‐miR‐424, hsa‐miR‐365 | miR‐192, miR‐194, miR‐196, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99 |
| RB1 | 44 (25–7) | RB1, hsa‐miR‐497 | hsa‐miR‐193b*, hsa‐miR‐365, hsa‐miR‐654‐3p, hsa‐miR‐424, hsa‐miR‐127‐3p, hsa‐miR‐377*, hsa‐miR‐455‐3p, hsa‐miR‐335 | miR‐192, miR‐194, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99 |
| Phosphatidyl‐inosiol signaling | 42 (27–7) | PIK3R1, CALM1, ITPR1, has‐miR‐497 | PIK3R2, INPPL1, hsa‐miR‐335, hsa‐miR‐424 | miR‐192, miR‐17, miR‐18, miR‐19, miR‐194, miR‐199, miR‐99, miR‐329 |
| DNA repair | 27 (16–9) | FANCG, ATM | hsa‐miR‐335, hsa‐miR‐424 | miR‐192, miR‐17, miR‐18, miR‐19, miR‐154 |
| ATR | 19 (13–10) | – | – | miR‐192, miR‐17, miR‐18, miR‐19, miR‐196, miR‐99 |
| Glycolysis and Gluconeogenesis | 6 (4–5) | FBP1, G6PC, ALDH9A1 | – |