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. 2015 May 8;9(8):1553–1564. doi: 10.1016/j.molonc.2015.04.008

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© 2015 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cyclin E copy number analysis. Representative pictures of Cyclin E copy number analyses as performed by fluorescence in situ hybridization (FISH) using Cyclin E specific probe (green) and centromere 11 specific probe (red). (A) Normal copy number. (B) Highly amplified Cyclin E locus in patient with progressive disease upon 5‐FU and mitomycin treatment. (C) Highly amplified Cyclin E locus in patient with progressive disease upon doxorubicin monotherapy treatment. Magnification 630×.