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. 2015 May 14;9(8):1626–1635. doi: 10.1016/j.molonc.2015.05.001

Figure 1.

Figure 1

Detection of nerve fibers in breast cancers. IHC for the neuronal marker PGP9.5 was performed on a series of 319 breast cancer samples. A) Nerve trunks (composed of many nerve fibers), occasionally present in breast tumors, were positive for PGP9.5. Perineural invasion (PNI) could be observed, as shown here. B–H) In some breast cancers, isolated nerve fibers (axons) positive for PGP9.5 were observed and are indicated by arrows. B) Nerve fibers around cancer cells and adipocytes (Ad). C) Nerve fibers in the tumor stroma (St) adjacent to cancer cells (CC). D) Enlargement of C. E, F) Nerve fibers among scattered breast cancer cells and in tumor stroma. G) Nerve fibers around an arteriole (Ar). H) Nerve fibers close to a thin walled blood vessel in the tumor stroma. Scale bar = 50 μm.