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Key molecular alterations in HCC as documented in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. This is a diagram illustrating the top 20 genes with highest prevalence of molecular alterations in patients with HCC. The most common among them are mutations in the TP53, ARID1A, CTNNB1, CDKN2A and ARID2 gene (http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/) at the time of this manuscript (March 24, 2014).
