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Proposed model illustrating the effect of autophagy on glioma phenotype. When autophagy is off, glioma cells show a typical mesenchymal phenotype with absence of cell–cell contacts, expression of SNAI proteins that repress cadherin transcription (left part of the cartoon). When autophagy is induced (right part of the cartoon), glioma cells loss SNAI proteins, with a consequent increase of cadherin expression so acquiring an epithelial‐like phenotype.
