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. 2015 Mar 19;9(7):1259–1273. doi: 10.1016/j.molonc.2015.03.003

Figure 1.

Figure 1

Modulation of NRF2 gene expression in normal and malignant ovarian epithelial cells by NRF2‐targeting ATFs. (A) Schematic overview of the NRF2 promoter region (transcript variant 1) containing the TSS (transcription start site, +1) and the target regions for the 6 engineered zinc finger proteins (ZFP OX1‐OX6). Histone modifications associated with ATF OX2 and OX5 were determined in ChIP region OX2‐ChIP6 and OX5‐ChIP5, respectively. CpGs are shown as vertical lines. (B) Relative NRF2 expression compared to empty vector control upon retroviral delivery of NRF2‐targeting ZFPs (OX1‐OX6) fused to the transcriptional repressor SKD in SKOV3, A2780 and OSE‐C2 cells. Relative NRF2 expression of the NRF2 cDNA control has only been determined in OSE‐C2 cells. Data is presented as mean ± SEM of at least three independent experiments. *p < 0.05.