Table 3.
Regression analyses relating leukocyte pro-inflammatory and pro-metastatic gene expression and social well-being in multivariable analyses in models (1 – 2) controlling for specified covariates.
| Model | Independent Variable | Dependent Variable | β (SE) | t | p | R2 Change |
|---|---|---|---|---|---|---|
|
1 2 |
Social Well-Being Social Well-Being |
Cytokine Composite*† Cytokine Composite |
−0.328 (0.040) −0.282 (0.040) |
−2.127 −1.825 |
0.039 0.075 |
0.089 0.063 |
|
1 2 |
Social Well-Being Social Well-Being |
Chemokine Composite*† Chemokine Composite |
−0.311 (0.040) −0.271 (0.040) |
−2.032 −1.755 |
0.048 0.087 |
0.080 0.058 |
|
1 2 |
Social Well-Being Social Well-Being |
Pro-Metastatic Composite**† Pro-Metastatic Composite**† |
−0.458 (0.026) −0.394 (0.025) |
−3.081 −2.735 |
0.004 0.009 |
0.173 0.124 |
|
1 2 |
Social Well-Being Social Well-Being |
IL1A*† IL1A* |
−0.397 (0.059) −0.350 (0.059) |
−2.624 −2.317 |
0.012 0.025 |
0.130 0.098 |
|
1 2 |
Social Well-Being Social Well-Being |
ILIB ILIB |
−0.216 (0.047) −0.178 (0.047) |
−1.378 −1.122 |
0.175 0.268 |
0.038 0.025 |
|
1 2 |
Social Well-Being Social Well-Being |
IL6 IL6 |
−0.242 (0.071) −0.197 (0.072) |
−1.535 −1.245 |
0.132 0.220 |
0.048 0.031 |
|
1 2 |
Social Well-Being Social Well-Being |
TNFSF10 TNFSF10 |
−0.117 (0.041) −0.107 (0.042) |
−0.719 −0.639 |
0.476 0.526 |
0.011 0.009 |
|
1 2 |
Social Well-Being Social Well-Being |
TNFRSF21† TNFRSF21 |
−0.302 (0.026) −0.268 (0.026) |
−2.006 −1.755 |
0.051 0.087 |
0.075 0.057 |
|
1 2 |
Social Well-Being Social Well-Being |
PTGS2/COX-2*† PTGS2/COX-2 |
−0.353 (0.042) −0.304 (0.042) |
−2.313 −1.999 |
0.026 0.052 |
0.103 0.073 |
|
1 2 |
Social Well-Being Social Well-Being |
CCL3 CCL3 |
−0.251 (0.048) −0.234 (0.049) |
−1.639 −1.487 |
0.109 0.145 |
0.052 0.043 |
|
1 2 |
Social Well-Being Social Well-Being |
CCL7 CCL7 |
−0.188 (0.046) −0.149 (0.047) |
−1.207 −0.946 |
0.234 0.350 |
0.029 0.018 |
|
1 2 |
Social Well-Being Social Well-Being |
CCL20*† CCL20 |
−0.332 (0.065) −0.286 (0.065) |
−2.158 −1.854 |
0.037 0.071 |
0.091 0.065 |
|
1 2 |
Social Well-Being Social Well-Being |
CCL3L1 CCL3L1 |
−0.245 (0.050) −0.218 (0.051) |
−1.593 −1.392 |
0.118 0.171 |
0.049 0.038 |
|
1 2 |
Social Well-Being Social Well-Being |
CCL4L2 CCL4L2 |
−0.273 (0.050) −0.234 (0.051) |
−1.767 −1.501 |
0.084 0.141 |
0.062 0.044 |
|
1 2 |
Social Well-Being Social Well-Being |
CXCR7† CXCR7 |
−0.280 (0.023) −0.248 (0.024) |
−1.976 −1.724 |
0.055 0.092 |
0.065 0.049 |
|
1 2 |
Social Well-Being Social Well-Being |
MMP9*† MMP9 |
−0.353 (0.032) −0.292 (0.032) |
−2.338 −1.982 |
0.024 0.054 |
0.102 0.068 |
|
1 2 |
Social Well-Being Social Well-Being |
LMNA**† LMNA**† |
−0.504 (0.024) −0.448 (0.024) |
−3.531 −3.203 |
0.001 0.003 |
0.210 0.160 |
*
p < 0.05
**
p < 0.01
†
Statistically significant after application of the Benjamini-Hochberg procedure at a false discovery rate of 0.10.
a
SE = Standard error. Model 1 analyses controlled for age, stage of disease, days since surgery, education, and BMI. Model 2 analyses controlled for age, stage of disease, days since surgery, education, BMI, and depression. Gene expression reported in RNA expression units (log2).