Table 4. Metabolites with significant difference between the control and the disease activity of NMOSD (C, healthy control; RL, relapse; RM, Remission).
| Metabolite | Multiple comparison (adjusted p-value*) | FDR*** | Metabolic change**** | Mean (SD) of group(mM) | |||
|---|---|---|---|---|---|---|---|
| RL | RM | C | RL | RM | |||
| 2-hydroxybutyrate | **RL-C(<0.001) RM-C(<0.001) | <0.05 <0.05 | Δ | Δ | 0.0420 (0.0086) | 0.0757 (0.0437) | 0.0697 (0.0303) |
| Acetone | RL-C(<0.001) RM-C(0.001) | <0.05 <0.05 | Δ | Δ | 0.1112 (0.0364) | 0.2125 (0.0760) | 0.2188 (0.0387) |
| Formate | RL-C(0.003) RM-C(0.004) | 0.019 0.018 | Δ | Δ | 0.0449 (0.0061) | 0.0579 (0.0168) | 0.0582 (0.0252) |
| Pyroglutamate | RL-C(0.006) RM-C(<0.001) | <0.05 <0.05 | Δ | Δ | 0.0332 (0.0030) | 0.0426 (0.0142) | 0.0437 (0.0080) |
| Acetate | C-RL(<0.001) C-RM(0.001) | <0.05 <0.05 | ∇ | ∇ | 0.2993 (0.0331) | 0.2460 (0.0393) | 0.2732 (0.0306) |
| Glucose | C-RL(0.001) C-RM(0.002) | <0.05 <0.05 | ∇ | ∇ | 4.5681 (0.2540) | 3.9866 (0.8970) | 4.3001 (1.1814) |
| Lactate | RL-C(<0.001) RM-C(0.002) | <0.05 <0.05 | Δ | Δ | 1.8832 (0.1715) | 2.5498 (0.8466) | 2.3316 (1.1543) |
| Isoleucine | RL-C(0.006) RM-C(0.002) | <0.05 <0.05 | Δ | Δ | 0.0079 (0.0013) | 0.0112 (0.0056) | 0.01188 (0.0062) |
* Adjusted p-value was calculated by Bonferroni’s correction.
** C, healthy control; RL, relapse; RM, Remission
*** FDR was calculated by Benjamini-Hochberg method.
**** Compared to the values of healthy controls, Δ indicates increase and ∇ indicates decrease.