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. 2015 Sep 30;10(2):195–212. doi: 10.1016/j.molonc.2015.09.008

Figure 4.

Figure 4

5‐HT7 receptor antagonist, SB‐258719, reduces proliferation of HuH‐7 and HepG2 cells and also down regulates β‐catenin. (A) Serum deprived HuH‐7 and HepG2 cells were subjected to different concentrations of SB‐258719 for 2 h followed by incubation with 5‐HT. Cell viability was detected by MTT. SB‐258719 inhibited the proliferative effect of 5‐HT (5‐HT vs 5‐HT + SB‐258719, ***P < 0.001, two‐way ANOVA). (B) SB‐258719 reduced β‐catenin protein levels in serum‐deprived HCC cells in the presence of 5‐HT compared to 5‐HT treatment alone in both HuH‐7 and HepG2 cells.