Table Table 2.
Clinical correlation of 5‐HT2A gene expression in HCC.
| Clinicopathological features | Frequency (%) | Receptor 5‐HT2A | P value | |
|---|---|---|---|---|
| Mean ± SD/number of patients | ||||
| Overexpression | ||||
| − | + | |||
| Age (year) | 0.101 | |||
| <53 | 15 (45.5) | 13 | 2 | |
| ≥53 | 18 (54.5) | 11 | 7 | |
| Sex | 0.191 | |||
| Male | 29 (87.9) | 20 | 9 | |
| Female | 4 (12.1) | 4 | 0 | |
| Non‐tumorous liver histology | 0.031 ∗ | |||
| Non‐cirrhotic | 2 (6.1) | 0 | 2 | |
| Chronic hepatitis | 16 (48.5) | 11 | 5 | |
| Cirrhotic | 15 (45.5) | 13 | 2 | |
| Tumour size (cm) a | 0.202 | |||
| <5 | 9 (27.3) | 8 | 1 | |
| ≥5 | 24 (72.7) | 16 | 8 | |
| Tumour recurrence | 0.825 | |||
| Absence | 12 (36.4) | 9 | 3 | |
| Presence | 21 (63.6) | 15 | 6 | |
| Venous infiltration b | 0.475 | |||
| Absence | 15 (45.5) | 10 | 5 | |
| Presence | 18 (54.5) | 14 | 4 | |
| Number of tumour nodules | 0.097 | |||
| 1 | 25 (75.8) | 20 | 5 | |
| ≥2 | 8 (24.2) | 4 | 4 | |
| Cellular differentiation c,d | 0.524 | |||
| Well differentiated | 11 (33.3) | 9 | 2 | |
| Moderately differentiated | 14 (42.4) | 10 | 4 | |
| Poorly differentiated | 7 (21.2) | 4 | 3 | |
| AJCC stage | 0.392 | |||
| I and II | 15 (45.5) | 12 | 3 | |
| III and IV | 18 (54.5) | 12 | 6 | |
*P < 0.05.
Tumour size was defined as the length of the largest tumour nodule.
Venous infiltration was defined based on findings by microscopic and major pathologic examination.
Well differentiated (Edmonson grade 0–2); moderately differentiated (Edmonson grade 3); poorly differentiated (Edmonson grade 4).
Partial data is not available and statistics were based on available data of 32 patients.