Table Table 4.
Clinical correlation of 5‐HT5 gene expression in HCC.
| Clinicopathological features | Frequency (%) | Receptor 5‐HT5 | P value | |
|---|---|---|---|---|
| Mean ± SD/number of patients | ||||
| Overexpression | ||||
| − | + | |||
| Age (year) | 0.658 | |||
| <53 | 15 (45.5) | 14 | 1 | |
| ≥53 | 18 (54.5) | 16 | 2 | |
| Sex | 0.238 | |||
| Male | 29 (87.9) | 27 | 2 | |
| Female | 4 (12.1) | 3 | 1 | |
| Non‐tumorous liver histology | 0.767 | |||
| Non‐cirrhotic | 2 (6.1) | 2 | 0 | |
| Chronic hepatitis | 16 (48.5) | 14 | 2 | |
| Cirrhotic | 15 (45.5) | 14 | 1 | |
| Tumour size (cm) a | 0.266 | |||
| <5 | 9 (27.3) | 9 | 0 | |
| ≥5 | 24 (72.7) | 21 | 3 | |
| Tumour recurrence | 0.170 | |||
| Absence | 12 (36.4) | 12 | 0 | |
| Presence | 21 (63.6) | 18 | 3 | |
| Venous infiltration b | 0.658 | |||
| Absence | 15 (45.5) | 14 | 1 | |
| Presence | 18 (54.5) | 16 | 2 | |
| Number of tumour nodules | 0.072 | |||
| 1 | 25 (75.8) | 24 | 1 | |
| ≥2 | 8 (24.2) | 6 | 2 | |
| Cellular differentiation c, d | 0.254 | |||
| Well differentiated | 11 (33.3) | 11 | 0 | |
| Moderately differentiated | 14 (42.4) | 12 | 2 | |
| Poorly differentiated | 7 (21.2) | 7 | 0 | |
| AJCC stage | 0.097 | |||
| I and II | 15 (45.5) | 15 | 0 | |
| III and IV | 18 (54.5) | 15 | 3 | |
*P < 0.05.
Tumour size was defined as the length of the largest tumour nodule.
Venous infiltration was defined based on findings by microscopic and major pathologic examination.
Well differentiated (Edmonson grade 0–2); moderately differentiated (Edmonson grade 3); poorly differentiated (Edmonson grade 4).
Partial data is not available and statistics were based on available data of 32 patients.