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. 2015 Nov 5;10(2):317–329. doi: 10.1016/j.molonc.2015.10.015

Figure 2.

Figure 2

CBP promoted the proliferation and migration of lung cancer cells. (A) Cell viability measured by MTT assay in different lung cancer cell lines following CBP knockdown or HAT activity inhibition. (B) Colony formation assay of H1299 and H322 cells treated with C646 or DMSO twice a week for two weeks. The quantification assay of the number of the colonies was also shown. (C) Cell migration assay in H1299 and H322 cells following CBP knockdown or activity inhibition, and the migration rate was calculated. (D) Western blot analysis of the expression of MMP‐9 protein in H1299 and H322 cells following CBP knockdown or activity inhibition. Both the colony formation assay and migration assay were done 3 times independently, and we selected the images from one time experiment in the result part. The mean ± SD in the quantitative analysis was calculated based on different counting and measurement for the colony number and migration distance from 3 different experiments. (*P < 0.05, **P < 0.01).