Fig. 3.

A rare synonymous LMNA variant segregates with DCM and conduction system disease. (A) The four-generation pedigree demonstrated autosomal dominant inheritance of the LMNA c.768 G > A variant (LOD = 20.02, θ = 0) and cardiomyopathy. (Solid symbols, affected; open symbols, unaffected; +, LMNA variant present; and −, LMNA variant absent). Analyses of lymphocyte (“L”) and cardiac (“H”) RNA was from the individuals indicated. (B) Kaplan–Meier curves of LMNA c.768G > A variant carriers, including (i) event-free survival from first diagnosis of the symptom, pacemaker implantation, and death; (ii) death-free survival comparing those with DCM to those without DCM; (iii) death-free survival; and (iv) transplant-free survival comparing male to female. P value was calculated by log-rank test.